Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression

• Published in: Gut Vol. 67; no. 8; pp. 1555 - 1557
• Main Authors: Stevens, Bruce R, Goel, Ruby, Seungbum, Kim, Richards, Elaine M, Holbert, Richard C, Pepine, Carl J, Raizada, Mohan K
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.08.2018
• Subjects: Anxiety; Biomarkers; Biosynthesis; Cholera Toxin; Depression; Digestive system; Dysbacteriosis; Epithelium; Fatty acid-binding protein; Fatty Acid-Binding Proteins; Fatty acids; Gastrointestinal Microbiome; Gastrointestinal tract; Genes; Genomics; Haptoglobins; Humans; Intestinal microflora; Intestine; Intestines; Mental disorders; Microbiomes; Microbiota; Permeability; Plasma; Protein Precursors; Tight junctions; Transfer RNA; Translation; Brazil; psychosomatic medicine; brain/gut interactions; intestinal barrier function; bacterial enterotoxin; enteric bacterial microflora

Zonulin is the master regulator of endothelial and epithelium tight junctions, modulating both gut and blood-brain barriers. 3 We analysed stool faecal microbiota and plasma in 50 subjects who self-reported to be asymptomatic for gastrointestinal physical disorders; 22 volunteers met Diagnostic and...