Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression

• Published in: Gut Vol. 67; no. 8; pp. 1555 - 1557
• Main Authors: Stevens, Bruce R, Goel, Ruby, Seungbum, Kim, Richards, Elaine M, Holbert, Richard C, Pepine, Carl J, Raizada, Mohan K
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.08.2018
• Subjects: Anxiety; Biomarkers; Biosynthesis; Cholera Toxin; Depression; Digestive system; Dysbacteriosis; Epithelium; Fatty acid-binding protein; Fatty Acid-Binding Proteins; Fatty acids; Gastrointestinal Microbiome; Gastrointestinal tract; Genes; Genomics; Haptoglobins; Humans; Intestinal microflora; Intestine; Intestines; Mental disorders; Microbiomes; Microbiota; Permeability; Plasma; Protein Precursors; Tight junctions; Transfer RNA; Translation; Brazil; psychosomatic medicine; brain/gut interactions; intestinal barrier function; bacterial enterotoxin; enteric bacterial microflora
• ISSN: 0017-5749; 1468-3288; 1468-3288
• DOI: 10.1136/gutjnl-2017-314759

Zonulin is the master regulator of endothelial and epithelium tight junctions, modulating both gut and blood-brain barriers. 3 We analysed stool faecal microbiota and plasma in 50 subjects who self-reported to be asymptomatic for gastrointestinal physical disorders; 22 volunteers met Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria for a depressive disorder or an anxiety disorder (DEP/ANX), and 28 more were control reference subjects (NODEPANX). Figure 2; Plasma LPS endotoxin, zonulin and fatty acid-binding protein-2 (FABP2) blood markers of gut dysbiosis and gut permeability pathophysiological epithelium integrity. 3 4 Analysis of variance yielded significant mean differences (p<0.05) (see online supplementary material ). Funding: University of Florida Clinical and Translational Science Institute grant (BRS, CJP) from the National Center For Advancing Translational Sciences of the National Institutes of Health under Award Number UL1TR001427; National Institute of Health (NIH) grants HL33610, HL56921 (MKR, CJP); UM1 HL087366 (CJP); Gatorade Trust through funds distributed by the University of Florida, Department of Medicine (CJP); PCORI-OneFlorida Clinical Research Consortium CDRN-1501-26692 (CJP); and internal funds from the University of Florida Department of Physiology and Functional Genomics (BRS, MKR).