Maternal high-fat diet programs Wnt genes through histone modification in the liver of neonatal rats

• Published in: Journal of molecular endocrinology Vol. 49; no. 2; pp. 107 - 114
• Main Authors: Yang, Ke-feng, Cai, Wei, Xu, Jia-li, Shi, Wen
• Format: Journal Article
• Language: English
• Published: England Society for Endocrinology 01.10.2012
• Subjects: Acetylation; Animals; Animals, Newborn; beta Catenin - metabolism; Body Weight; Diet, High-Fat; Female; Gene Expression Regulation, Developmental; Histones - metabolism; Lactation; Liver - metabolism; Lysine - metabolism; Maternal Nutritional Physiological Phenomena; Pregnancy; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Regular papers; Signal Transduction; Wnt Proteins - genetics; Wnt Proteins - metabolism; Wnt1 Protein - genetics; Wnt1 Protein - metabolism

Maternal high-fat (HF) diets during gestation and lactation have been shown to contribute to metabolic disorders in offspring. Molecular and epigenetic mechanisms underlying this connection may be essential for the prevention and treatment of the fetal origins of metabolic diseases. The current stud...