Maternal high-fat diet programs Wnt genes through histone modification in the liver of neonatal rats

Maternal high-fat (HF) diets during gestation and lactation have been shown to contribute to metabolic disorders in offspring. Molecular and epigenetic mechanisms underlying this connection may be essential for the prevention and treatment of the fetal origins of metabolic diseases. The current stud...

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Bibliographic Details
Published inJournal of molecular endocrinology Vol. 49; no. 2; pp. 107 - 114
Main Authors Yang, Ke-feng, Cai, Wei, Xu, Jia-li, Shi, Wen
Format Journal Article
LanguageEnglish
Published England Society for Endocrinology 01.10.2012
Subjects
Acetylation
Animals
Animals, Newborn
beta Catenin - metabolism
Body Weight
Diet, High-Fat
Female
Gene Expression Regulation, Developmental
Histones - metabolism
Lactation
Liver - metabolism
Lysine - metabolism
Maternal Nutritional Physiological Phenomena
Pregnancy
Promoter Regions, Genetic
Rats
Rats, Sprague-Dawley
Regular papers
Signal Transduction
Wnt Proteins - genetics
Wnt Proteins - metabolism
Wnt1 Protein - genetics
Wnt1 Protein - metabolism
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Summary:Maternal high-fat (HF) diets during gestation and lactation have been shown to contribute to metabolic disorders in offspring. Molecular and epigenetic mechanisms underlying this connection may be essential for the prevention and treatment of the fetal origins of metabolic diseases. The current study examined the impact of maternal HF diets on Wnt signaling and histone modification in offspring. Time-pregnant Sprague–Dawley rats were fed either control diet or HF diet during gestation and lactation and then the neonatal offspring of both groups were investigated. The neonatal offspring born to dams fed on HF diets exhibited increases in serum glucose and liver triglyceride levels. Maternal exposure to the HF diet also repressed the mRNA expression of Wnt1 and nuclear β-catenin protein in the liver of offspring. The altered Wnt1 gene expression may be due to the changes of acetylation of H4 at its promoter as well as acetylation of H4 and methylation of H3K9 at coding region. Maternal exposure to the HF diet induced suppression of the Wnt/β-catenin signaling pathway through histone modification, potentially increasing the risk of metabolic syndrome.
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ISSN:0952-5041
1479-6813
DOI:10.1530/JME-12-0046