Emerging functional roles of nuclear receptors in breast cancer

Nuclear receptors (NRs) have been targets of intensive drug development for decades due to their roles as key regulators of multiple developmental, physiological and disease processes. In breast cancer, expression of the estrogen and progesterone receptor remains clinically important in predicting p...

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Bibliographic Details
Published inJournal of molecular endocrinology Vol. 58; no. 3; pp. R169 - R190
Main Authors Doan, Tram B, Graham, J Dinny, Clarke, Christine L
Format Journal Article
LanguageEnglish
Published England Bioscientifica Ltd 01.04.2017
Subjects
Animals
Biomarkers
Breast - metabolism
Breast Neoplasms - etiology
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - metabolism
Cellular Reprogramming - genetics
Chromatin - genetics
Chromatin - metabolism
Circadian Clocks - genetics
Disease Progression
Energy Metabolism
Female
Gene Expression Regulation
Genetic Association Studies
Humans
Multigene Family
Organ Specificity - genetics
Protein Binding
Receptors, Cytoplasmic and Nuclear - chemistry
Receptors, Cytoplasmic and Nuclear - genetics
Receptors, Cytoplasmic and Nuclear - metabolism
Review
Signal Transduction
nuclear receptors
breast cancer
metabolism
circadian clock
migration and metastasis
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Summary:Nuclear receptors (NRs) have been targets of intensive drug development for decades due to their roles as key regulators of multiple developmental, physiological and disease processes. In breast cancer, expression of the estrogen and progesterone receptor remains clinically important in predicting prognosis and determining therapeutic strategies. More recently, there is growing evidence supporting the involvement of multiple nuclear receptors other than the estrogen and progesterone receptors, in the regulation of various processes important to the initiation and progression of breast cancer. We review new insights into the mechanisms of action of NRs made possible by recent advances in genomic technologies and focus on the emerging functional roles of NRs in breast cancer biology, including their involvement in circadian regulation, metabolic reprogramming and breast cancer migration and metastasis.
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ISSN:0952-5041
1479-6813
DOI:10.1530/JME-16-0082