Severe chorea with positive anti-basal ganglia antibodies after herpesencephalitis

According to these findings, high-dose intravenous methylprednisolone (20 mg/kg/day for 3 days) was given, but remained clinically ineffective. On the contrary, systemic immunosuppression inhibits ongoing systemic as well as autochthonous ABGA production. [...]a combination of these two approaches i...

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Published inJournal of neurology, neurosurgery and psychiatry Vol. 78; no. 1; pp. 105 - 107
Main Authors Marschitz, I, Rödl, S, Gruber-Sedlmayr, U, Church, A, Giovannoni, G, Zobel, G, Mache, C J, Raith, J, Plecko, B
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group Ltd 01.01.2007
BMJ Publishing Group LTD
BMJ Group
Subjects
Antibodies - blood
Antibodies - cerebrospinal fluid
Antibody Formation
Antigens
Basal Ganglia - immunology
Child, Preschool
Chorea - immunology
Compulsive Behavior - etiology
Drugs
Encephalitis
Encephalitis, Herpes Simplex - complications
Encephalitis, Herpes Simplex - immunology
Female
Herpes viruses
Humans
Immunoglobulins
Letters
Patients
Plasma
Ventilation
Viral infections
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Summary:According to these findings, high-dose intravenous methylprednisolone (20 mg/kg/day for 3 days) was given, but remained clinically ineffective. On the contrary, systemic immunosuppression inhibits ongoing systemic as well as autochthonous ABGA production. [...]a combination of these two approaches is reasonable.
Bibliography:href:jnnp-78-105.pdf
ark:/67375/NVC-5SB0KC0F-B
Correspondence to:
 B Plecko
 Department of Pediatrics, Medical University Graz, Auenbruggerplatz 30, A-8036 Graz, Austria;barbara.plecko@meduni-graz.at
istex:AF80123F241799349F811D9FF5267BD59C0DEF73
PMID:17172578
local:0780105
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.2006.090555