Altered glial plasticity in animal models for mood disorders

• Published in: Current drug targets Vol. 14; no. 11; p. 1249
• Main Authors: Czéh, Boldizsár, Fuchs, Eberhard, Flügge, Gabriele
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.10.2013
• Subjects: Animals; Antidepressive Agents - therapeutic use; Astrocytes - drug effects; Astrocytes - pathology; Astrocytes - physiology; Brain - pathology; Brain - physiopathology; Depressive Disorder, Major - pathology; Depressive Disorder, Major - physiopathology; Depressive Disorder, Major - psychology; Disease Models, Animal; Humans; Neurogenesis; Neuroglia - drug effects; Neuroglia - pathology; Neuroglia - physiology; Neuronal Plasticity - genetics

Numerous clinical evidences support the notion that glial changes in fronto-limbic brain areas could contribute to the pathophysiology of mood disorders. Glial alterations have been reported not only in patients, but also in various kinds of animal models for depression. Molecular and cellular data...