Altered glial plasticity in animal models for mood disorders

Numerous clinical evidences support the notion that glial changes in fronto-limbic brain areas could contribute to the pathophysiology of mood disorders. Glial alterations have been reported not only in patients, but also in various kinds of animal models for depression. Molecular and cellular data...

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Bibliographic Details
Published inCurrent drug targets Vol. 14; no. 11; p. 1249
Main Authors Czéh, Boldizsár, Fuchs, Eberhard, Flügge, Gabriele
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.10.2013
Subjects
Animals
Antidepressive Agents - therapeutic use
Astrocytes - drug effects
Astrocytes - pathology
Astrocytes - physiology
Brain - pathology
Brain - physiopathology
Depressive Disorder, Major - pathology
Depressive Disorder, Major - physiopathology
Depressive Disorder, Major - psychology
Disease Models, Animal
Humans
Neurogenesis
Neuroglia - drug effects
Neuroglia - pathology
Neuroglia - physiology
Neuronal Plasticity - genetics
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Summary:Numerous clinical evidences support the notion that glial changes in fronto-limbic brain areas could contribute to the pathophysiology of mood disorders. Glial alterations have been reported not only in patients, but also in various kinds of animal models for depression. Molecular and cellular data suggest that all the major classes of glial cells are affected in these conditions, including astrocytes, oligodendrocytes, NG2-positive cells and microglia. The aim of this review was to summarize the currently available experimental results demonstrating alterations in glial morphology and functioning in animal models for mood disorders. Better understanding of these glial changes affecting neuronal activity could help us to identify novel targets for the development of antidepressant drugs.
ISSN:1873-5592
DOI:10.2174/1389450111314110005