Effect of aging on metabolic pathways in endothelial progenitor cells

Age represents a significant risk factor for the onset and progression of cardiovascular disease, with the increase in life expectancy in developed countries going in parallel with increased incidence of such pathologies. Treatment strategies alternative or additive to pharmacological treatments are...

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Published inCurrent pharmaceutical design Vol. 19; no. 13; p. 2351
Main Authors Felice, Francesca, Barsotti, Maria Chiara, Poredos, Pavel, Balbarini, Alberto, Di Stefano, Rossella
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.04.2013
Subjects
Aging - metabolism
Animals
Endothelium - metabolism
Humans
Neovascularization, Physiologic
Stem Cells - metabolism
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Summary:Age represents a significant risk factor for the onset and progression of cardiovascular disease, with the increase in life expectancy in developed countries going in parallel with increased incidence of such pathologies. Treatment strategies alternative or additive to pharmacological treatments are needed. The relationship between aging and progenitor cell-mediated repair is of great interest. Endothelial progenitor cells (EPC) mediate repair mechanisms for endothelial regeneration and maintenance, but they are subject to age-associated changes affecting negatively their number and/or function. Aim of this review is to examine the impact of age on EPC-mediated vascular repair, with a focus on the metabolic pathways involved and on the therapeutic targets with potential for attenuating this effect.
ISSN:1873-4286
DOI:10.2174/1381612811319130003