Effects of xylazine on renal function and plasma glucose in ponies

The intravenous administration of xylazine (1.1 mg/kg bodyweight) in six ponies resulted in a significant increase in urine output over two hours, with maximum flow occurring between 30 and 60 minutes after injection. Urine specific gravity, osmolality and glucose concentration decreased. Renal clea...

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Bibliographic Details
Published inVeterinary record Vol. 118; no. 3; pp. 65 - 67
Main Authors Trim, C.M, Hanson, R.R
Format Journal Article
LanguageEnglish
Published England 18.01.1986
Subjects
Animals
Arousal - drug effects
blood glucose
Blood Glucose - metabolism
electrolytes
Electrolytes - urine
Glomerular Filtration Rate - drug effects
Horses
Kidney - drug effects
Kidney Concentrating Ability - drug effects
Kidney Function Tests
Male
renal function
Thiazines - pharmacology
urine
Urodynamics - drug effects
xylazine
Xylazine - pharmacology
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Summary:The intravenous administration of xylazine (1.1 mg/kg bodyweight) in six ponies resulted in a significant increase in urine output over two hours, with maximum flow occurring between 30 and 60 minutes after injection. Urine specific gravity, osmolality and glucose concentration decreased. Renal clearance of endogenous creatinine was unchanged. Significant increases in the excretion of potassium and chloride occurred. Plasma glucose concentration was increased 30 minutes after the administration of xylazine by a mean value of 37 per cent. Serum osmolality and sodium, potassium and chloride concentrations remained unchanged.
ISSN:0042-4900
2042-7670
DOI:10.1136/vr.118.3.65