Cross-metathesis: efficient preparation of trialkyl-substituted isoprenoid olefins as key-intermediates for tocopherol synthesis

A summary of the application of ruthenium catalyzed olefin cross-metathesis towards the synthesis of tocopherols (vitamin E) is given. This group of biologically important fat-soluble antioxidants is synthetically available by various routes, for which key-intermediates containing trialkyl-substitut...

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Published inCurrent topics in medicinal chemistry Vol. 5; no. 15; p. 1579
Main Author Netscher, Thomas
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2005
Subjects
Alkenes - chemical synthesis
Alkenes - chemistry
Catalysis
Cyclization
Molecular Structure
Organometallic Compounds - chemistry
Ruthenium - chemistry
Stereoisomerism
Tocopherols - chemical synthesis
Tocopherols - chemistry
Online AccessGet more information
ISSN1568-0266
DOI10.2174/156802605775009775

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Abstract A summary of the application of ruthenium catalyzed olefin cross-metathesis towards the synthesis of tocopherols (vitamin E) is given. This group of biologically important fat-soluble antioxidants is synthetically available by various routes, for which key-intermediates containing trialkyl-substituted olefinic double bonds can now be prepared efficiently. The results presented may be of interest for the area of syntheses of isoprenoid natural products in general.
AbstractList A summary of the application of ruthenium catalyzed olefin cross-metathesis towards the synthesis of tocopherols (vitamin E) is given. This group of biologically important fat-soluble antioxidants is synthetically available by various routes, for which key-intermediates containing trialkyl-substituted olefinic double bonds can now be prepared efficiently. The results presented may be of interest for the area of syntheses of isoprenoid natural products in general.
Author Netscher, Thomas
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  organization: Research and Development, DSM Nutritional Products, P.O. Box 3255, CH-4002 Basel, Switzerland. thomas.netscher@dsm.com
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CitedBy_id crossref_primary_10_3390_molecules22020233
crossref_primary_10_1002_chin_200637219
crossref_primary_10_1007_s00706_012_0905_3
crossref_primary_10_1016_j_ccr_2006_11_002
crossref_primary_10_1021_ol9020783
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Snippet A summary of the application of ruthenium catalyzed olefin cross-metathesis towards the synthesis of tocopherols (vitamin E) is given. This group of...
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StartPage 1579
SubjectTerms Alkenes - chemical synthesis
Alkenes - chemistry
Catalysis
Cyclization
Molecular Structure
Organometallic Compounds - chemistry
Ruthenium - chemistry
Stereoisomerism
Tocopherols - chemical synthesis
Tocopherols - chemistry
Title Cross-metathesis: efficient preparation of trialkyl-substituted isoprenoid olefins as key-intermediates for tocopherol synthesis
URI https://www.ncbi.nlm.nih.gov/pubmed/16378493
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