Cross-metathesis: efficient preparation of trialkyl-substituted isoprenoid olefins as key-intermediates for tocopherol synthesis

A summary of the application of ruthenium catalyzed olefin cross-metathesis towards the synthesis of tocopherols (vitamin E) is given. This group of biologically important fat-soluble antioxidants is synthetically available by various routes, for which key-intermediates containing trialkyl-substitut...

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Bibliographic Details
Published inCurrent topics in medicinal chemistry Vol. 5; no. 15; p. 1579
Main Author Netscher, Thomas
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2005
Subjects
Alkenes - chemical synthesis
Alkenes - chemistry
Catalysis
Cyclization
Molecular Structure
Organometallic Compounds - chemistry
Ruthenium - chemistry
Stereoisomerism
Tocopherols - chemical synthesis
Tocopherols - chemistry
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ISSN1568-0266
DOI10.2174/156802605775009775

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Summary:A summary of the application of ruthenium catalyzed olefin cross-metathesis towards the synthesis of tocopherols (vitamin E) is given. This group of biologically important fat-soluble antioxidants is synthetically available by various routes, for which key-intermediates containing trialkyl-substituted olefinic double bonds can now be prepared efficiently. The results presented may be of interest for the area of syntheses of isoprenoid natural products in general.
ISSN:1568-0266
DOI:10.2174/156802605775009775