A variance component analysis on recombination rate in the COGA pedigrees

We estimated the crossover frequency in 1,232 gametes from 356 subjects in pedigrees from the Collaborative Study on the Genetics on Alcoholism. We examined the effect of covariates including age, ethnicity, and years with ALDX1 on recombination rate, and found a positive correlation between recombi...

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Bibliographic Details
Published inBMC genetics Vol. 6; no. S1; p. S58
Main Authors Wang, Lin, Xu, Xin
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 30.12.2005
BioMed Central
Subjects
Alcoholism - genetics
Analysis of Variance
Chromosomes, Human - genetics
Cooperative Behavior
Crossing Over, Genetic
Female
Genetic Linkage
Humans
Male
Models, Genetic
Pedigree
Proceedings
Recombination, Genetic - genetics
Regression Analysis
Sex Characteristics
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Summary:We estimated the crossover frequency in 1,232 gametes from 356 subjects in pedigrees from the Collaborative Study on the Genetics on Alcoholism. We examined the effect of covariates including age, ethnicity, and years with ALDX1 on recombination rate, and found a positive correlation between recombination rate and years with ALDX1. By variance-component analysis, we estimated the heritability of recombination rate to be around 0.5, and provided suggestive evidence for a locus linked to recombination rate.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1471-2156
1471-2156
DOI:10.1186/1471-2156-6-S1-S58