Coronary Endothelial Dysfunction in Women With Type 2 Diabetes Measured by Coronary Phase Contrast Flow Velocity Magnetic Resonance Imaging

• Published in: Journal of investigative medicine Vol. 63; no. 7; pp. 856 - 861
• Main Authors: Maroules, Christopher D., Chang, Alice Y., Kotys-Traughber, Melanie S., Peshock, Ronald M.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.10.2015; Sage Publications Ltd
• Subjects: Adult; Blood Flow Velocity; Coronary Circulation; Coronary Vessels - physiopathology; Diabetes Mellitus, Type 2 - physiopathology; Endothelium, Vascular - physiopathology; Female; Flow velocity; Humans; Magnetic Resonance Imaging - methods; Medical imaging; Microscopes; NMR; Nuclear magnetic resonance; Rodents; coronary flow; cardiac magnetic resonance; endothelial dysfunction; coronary blood flow reserve
• ISSN: 1081-5589; 1708-8267; 1708-8267
• DOI: 10.1097/JIM.0000000000000226

ObjectiveThe aim of this study was to determine if differences in coronary endothelial function are observed between asymptomatic women with type 2 diabetes mellitus (DM) and control subjects using coronary phase contrast flow velocity magnetic resonance imaging in response to cold pressor stress, an established endothelium-dependent vasodilatory stress.MethodsPhase contrast flow velocity imaging of the right coronary artery was performed in 7 asymptomatic premenopausal women with DM and 8 healthy female participants in response to the cold pressor test at 3 T.ResultsThere was no significant difference in percent increase in coronary flow velocity from rest to peak flow velocity between DM and control subjects (32% ± 22% vs 46% ± 17%; P = 0.11). However, percent increase in coronary flow velocity was lower in DM than in control subjects (−3% ± 14% vs 31% ± 30%; P = 0.01) during the second minute of cold pressor stress, when endothelial-mediated vasodilation should occur.ConclusionsAsymptomatic women with DM demonstrate reduced coronary flow velocity during the second minute of cold pressor stress, indicating coronary endothelial dysfunction.