Infection of Aotus and Saimiri Monkeys with Plasmodium gonderi

• Published in: The Journal of parasitology Vol. 88; no. 2; pp. 422 - 425
• Main Authors: Sullivan, JoAnn S, Jennings, Veronica M, Guarner, Jeanette, Noland, Gregory S, Kendall, Jesse, Collins, William E
• Format: Journal Article
• Language: English
• Published: Lawrence, KS American Society of Parasitologists 01.04.2002
• Subjects: Animals; Biological and medical sciences; Biopsy - veterinary; Blood; Cebidae; Disease Models, Animal; Erythrocytes - parasitology; Erythrocytes - pathology; Experimental protozoal diseases and models; Infections; Infectious diseases; Inoculation; Liver; Liver - parasitology; Malaria - blood; Malaria - parasitology; Malaria - transmission; Malaria - veterinary; Medical sciences; Monkey Diseases - blood; Monkey Diseases - parasitology; Monkey Diseases - transmission; Monkeys; Mosquitos; Parasites; Parasitic diseases; Parasitology; Plasmodium - growth & development; Protozoal diseases; RESEARCH NOTES; Sporozoites; Protozoa; Host parasite relation; Apicomplexa; Protozoal disease; Malaria; Interspecific comparison; Liver; Parasite; Host; Sporozoit; Parasitosis; Exoerythrocytic cycle; Infection; Vertebrata; Experimental disease; Mammalia; Histopathology; Aotus trivirgatus; Primates; Simioidea
• ISSN: 0022-3395; 1937-2345
• DOI: 10.1645/0022-3395(2002)088[0422:IOAASM]2.0.CO;2

Attempts were made to infect 4 species of New World monkeys (Saimiri boliviensis, Aotus nancymai, A. vociferans, A. azarae boliviensis) with Plasmodium gonderi, a malaria parasite of African monkeys. Sporozoites were obtained from Anopheles dirus or A. stephensi mosquitoes that fed on an infected rhesus monkey (Macaca mulatta). Inoculation of sporozoites was by injection of dissected sporozoites by either the intravenous or intrahepatic routes, or by mosquito bite. Liver biopsies done 7 or 8 days after sporozoite inoculation showed that hepatocytes of all 4 species of these New World monkeys supported exoerythrocytic stages of P. gonderi, but daily blood film examination during a 60-day observation period failed to detect blood stages of the parasite.