Novel 2-(2-benzylidenehydrazinyl)benzo[d]thiazole as potential antitubercular agents

• Published in: Combinatorial chemistry & high throughput screening Vol. 16; no. 3; p. 244
• Main Authors: Bairwa, Vinod Kumar, Telvekar, Vikas N
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.03.2013
• Subjects: Antitubercular Agents - chemical synthesis; Antitubercular Agents - chemistry; Antitubercular Agents - pharmacology; Humans; Microbial Sensitivity Tests; Mycobacterium tuberculosis - drug effects; Structure-Activity Relationship; Thiazoles - chemical synthesis; Thiazoles - chemistry; Thiazoles - pharmacology; Tuberculosis - drug therapy
• ISSN: 1875-5402
• DOI: 10.2174/1386207311316030009

Molecular hybridization approach was used to synthesize substituted 2-(2-(4-aryl oxy benzylidene) hydrazinyl)benzo thiazole derivatives with 2-hydrazinobenzothiazole and 4-(alicycli/aryl/biaryl/heteroaryl oxy)benzaldehyde as new anti-TB agents. The synthesized compounds, when tested against H37Rv strains of Mtb using Resazurin Microtitre Assay (REMA) method, showed promising activity (MIC 1.35-36.50 μg/mL). 6-chloro-2-(2-(4- (pyridin-4-yloxy) benzylidene) hydrazinyl) benzo[d]thiazole (10v) gave MIC of 1.35 μg/mL. Thus making it, a potential lead could be developed for further antitubercular studies.