Efficient cell chatting between embryo and uterus ensures embryo implantation

Embryo implantation is one of the hottest topics during female reproduction since it is the first dialogue between maternal uterus and developing embryo whose disruption will contribute to adverse pregnancy outcome. Numerous achievements have been made to decipher the underlying mechanism of embryo...

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Published inBiology of reproduction Vol. 107; no. 1; pp. 339 - 348
Main Authors Deng, Wenbo, Wang, Haibin
Format Journal Article
LanguageEnglish
Published Cary Society for the Study of Reproduction 25.07.2022
Oxford University Press
Subjects
activation
Blood vessels
Cell cycle
China Special Issue
Communication
diapause
Embryo implantation
embryonic signal
Embryos
Endometrium
Epigenetics
Estrogens
Fetuses
Gene expression
Gynecology
Hormones
Hospitals
Implantation
Infertility
Laboratories
Medical research
Obstetrics
Pregnancy
Reproductive health
Steroids
Tumor necrosis factor-TNF
Uterus
diapause
Embryo implantation
embryonic signal
activation
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Summary:Embryo implantation is one of the hottest topics during female reproduction since it is the first dialogue between maternal uterus and developing embryo whose disruption will contribute to adverse pregnancy outcome. Numerous achievements have been made to decipher the underlying mechanism of embryo implantation by genetic and molecular approaches accompanied with emerging technological advances. In recent decades, raising concepts incite insightful understanding on the mechanism of reciprocal communication between implantation competent embryos and receptive uterus. Enlightened by these gratifying evolvements, we aim to summarize and revisit current progress on the critical determinants of mutual communication between maternal uterus and embryonic signaling on the perspective of embryo implantation to alleviate infertility, enhance fetal health, and improve contraceptive design. Summary Sentence We revisit the progress on the critical determinants of mutual communication between maternal uterus and embryonic signaling on the perspective of embryo implantation and aim to advance the mechanism study of embryo implantation and ultimately alleviate infertility, enhance fetal health, and improve contraceptive design.
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Grant Support: This work was partially supported by the National Key R&D program of China (2021YFC2700302 to H.W.; 2018YFC1004100 to W.D.), National Natural Science Foundation of China (81830045 and 82030040 to H.W.; 32171117, 82122026, 81971419 and 81701483 to W.D.), Natural Science Foundation of Fujian Province of China (2020J01020 to W.D.), and Fundamental Research Funds for the Central Universities (20720190073 to W.D.).
ISSN:0006-3363
1529-7268
1529-7268
DOI:10.1093/biolre/ioac135