Understanding the structure, activity and inhibition of chorismate synthase from Mycobacterium tuberculosis

Tuberculosis is considered a worldwide health problem mainly due to co-infection with HIV and proliferation of multi-drug-resistant strains. The enzymes of the shikimate pathway are potential targets for the development of new therapies because they are essential for bacteria, but absent from mammal...

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Bibliographic Details
Published inCurrent medicinal chemistry Vol. 18; no. 9; p. 1311
Main Authors Arcuri, H A, Palma, M S
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.03.2011
Subjects
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Flavin Mononucleotide - chemistry
Mycobacterium tuberculosis - enzymology
Phosphorus-Oxygen Lyases - antagonists & inhibitors
Phosphorus-Oxygen Lyases - chemistry
Phosphorus-Oxygen Lyases - metabolism
Protein Structure, Tertiary
Shikimic Acid - metabolism
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Summary:Tuberculosis is considered a worldwide health problem mainly due to co-infection with HIV and proliferation of multi-drug-resistant strains. The enzymes of the shikimate pathway are potential targets for the development of new therapies because they are essential for bacteria, but absent from mammals. The last step in this pathway is performed by chorismate synthase (CS), which catalyzes the conversion of 5-enolpyruvylshikimate-3-phosphate (EPSP) to chorismate. The aim of this article is to review the available information on chorismate synthase from Mycobacterium tuberculosis.
ISSN:1875-533X
DOI:10.2174/092986711795029528