Chemistry, biological properties and SAR analysis of quinoxalinones

Quinoxaline derivatives have received much attention in recent years owing to their both biological properties and pharmaceutical applications. In this review we focus the attention on quinoxalin-2(3)-ones and quinoxalin-2,3-diones. These derivatives are particularly interesting since some of them s...

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Bibliographic Details
Published inMini reviews in medicinal chemistry Vol. 6; no. 11; p. 1179
Main Authors Carta, A, Piras, S, Loriga, G, Paglietti, G
Format Journal Article
LanguageEnglish
Published Netherlands 01.11.2006
Subjects
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cell Proliferation - drug effects
Excitatory Amino Acid Antagonists - chemistry
Excitatory Amino Acid Antagonists - pharmacology
Humans
Quinoxalines - chemistry
Quinoxalines - pharmacology
Structure-Activity Relationship
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Summary:Quinoxaline derivatives have received much attention in recent years owing to their both biological properties and pharmaceutical applications. In this review we focus the attention on quinoxalin-2(3)-ones and quinoxalin-2,3-diones. These derivatives are particularly interesting since some of them showed antimicrobial (against several bacteria, viruses, fungi, etc), or anticancer activities. Furthermore, others are reported to be potent no-NMDA glutamate receptor antagonists, endowed with anxiolytic, deconditioning, analgesic, antispastic, antiallergic, antithrombotic activities. In this article we also report SAR studies and the most important methods of synthesis of the quinoxalin-2(3)-(di)ones.
ISSN:1389-5575
DOI:10.2174/138955706778742713