Future target molecules for influenza treatment

Induction of apoptosis and pro-inflammatory cytokine gene expression in influenza virus-infected cells activates production of toxic superoxide by macrophages. Pyrrolidine dithiocarbamate and nordihydroguaiaretic acid inhibit influenza virus proliferation and scavenge superoxide. These results sugge...

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Bibliographic Details
Published inMini reviews in medicinal chemistry Vol. 8; no. 5; p. 491
Main Authors Uchide, N, Toyoda, H
Format Journal Article
LanguageEnglish
Published Netherlands 01.05.2008
Subjects
Apoptosis - drug effects
Cell Proliferation - drug effects
Cytokines - drug effects
Cytokines - genetics
Cytokines - immunology
Gene Expression - drug effects
Humans
Influenza, Human - drug therapy
Influenza, Human - genetics
Influenza, Human - metabolism
Masoprocol - chemistry
Masoprocol - pharmacology
Masoprocol - therapeutic use
Pyrrolidines - chemistry
Pyrrolidines - pharmacology
Pyrrolidines - therapeutic use
Superoxides - antagonists & inhibitors
Thiocarbamates - chemistry
Thiocarbamates - pharmacology
Thiocarbamates - therapeutic use
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Summary:Induction of apoptosis and pro-inflammatory cytokine gene expression in influenza virus-infected cells activates production of toxic superoxide by macrophages. Pyrrolidine dithiocarbamate and nordihydroguaiaretic acid inhibit influenza virus proliferation and scavenge superoxide. These results suggest that they can be potential candidates for a drug of choice for influenza chemotherapy.
ISSN:1389-5575
DOI:10.2174/138955708784223530