Length of pseudopregnancy and pattern of uterine protein release as influenced by time and duration of oestrogen administration in the pig

Treatment of gilts with 5 mg oestradiol benzoate on Day 9.5, 11, 12.5, 14, 15.5 or Days 14-16 resulted in an interoestrous interval of about 30 days. Administration of oestradiol benzoate daily from Days 11 to 15 or two periods of treatment on Days 11 and 14 to 16 resulted in prolonging CL function...

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Bibliographic Details
Published inJournal of reproduction & fertility Vol. 79; no. 1; pp. 163 - 172
Main Authors Geisert, R.D, Zavy, M.T, Wettemann, R.P, Biggers, B.G
Format Journal Article
LanguageEnglish
Published England 1987
Subjects
Animals
Endometrium - drug effects
Endometrium - metabolism
Estradiol - pharmacology
estrogens
Female
protein transport
Proteins - metabolism
Pseudopregnancy
stimulation
Swine
Time Factors
uterus
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Summary:Treatment of gilts with 5 mg oestradiol benzoate on Day 9.5, 11, 12.5, 14, 15.5 or Days 14-16 resulted in an interoestrous interval of about 30 days. Administration of oestradiol benzoate daily from Days 11 to 15 or two periods of treatment on Days 11 and 14 to 16 resulted in prolonging CL function beyond 60 days from the pre-treatment oestrus. Endometrial secretory response to oestrogen stimulation, based on the ability of oestrogen to release calcium and uterine protein into the lumen appears to occur after Day 10 of the oestrous cycle. The results suggest that maintenance of prolonged CL function appears to require two periods of oestrogen stimulation. The first period occurs on Day 11 when the endometrium has become responsive to oestrogen stimulation followed by a second prolonged increase in oestrogen stimulation after Day 14. These findings accord with the normal patterns of oestrogen released by pig blastocysts during early pregnancy.
ISSN:0022-4251
1470-1626
1741-7899
DOI:10.1530/jrf.0.0790163