Diagnostic ability of peripapillary vessel density measurements of optical coherence tomography angiography in primary open-angle and angle-closure glaucoma

• Published in: British journal of ophthalmology Vol. 101; no. 8; pp. 1066 - 1070
• Main Authors: Rao, Harsha L, Kadambi, Sujatha V, Weinreb, Robert N, Puttaiah, Narendra K, Pradhan, Zia S, Rao, Dhanaraj A S, Kumar, Rajesh S, Webers, Carroll A B, Shetty, Rohit
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.08.2017
• Subjects: Aged; Algorithms; Biometrics; Case-Control Studies; Computed Tomography Angiography - methods; Cross-Sectional Studies; Experts; Family medical history; Female; Glaucoma; Glaucoma, Angle-Closure - diagnostic imaging; Glaucoma, Open-Angle - diagnostic imaging; Humans; Male; Medical diagnosis; Medical imaging; Middle Aged; Nerve Fibers; Ophthalmology; Optics; Retinal Vessels - diagnostic imaging; ROC Curve; Tomography; Tomography, Optical Coherence - methods; United States > US; California; Glaucoma; Imaging
• ISSN: 0007-1161; 1468-2079; 1468-2079
• DOI: 10.1136/bjophthalmol-2016-309377

AimsTo evaluate the diagnostic ability of peripapillary vessel density measurements on optical coherence tomography angiography (OCTA) in primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG), and to compare these with peripapillary retinal nerve fibre layer (RNFL) thickness measurements.MethodsIn a cross-sectional study, 48 eyes of 33 healthy control subjects, 63 eyes of 39 patients with POAG and 49 eyes of 32 patients with PACG underwent OCTA (RTVue-XR, Optovue, Fremont, California, USA) and RNFL imaging with spectral domain OCT. Diagnostic abilities of vessel density and RNFL parameters were evaluated using area under receiver operating characteristic curves (AUC) and sensitivities at fixed specificities.ResultsAUCs of peripapillary vessel density ranged between 0.48 for the temporal sector and 0.88 for the inferotemporal sector in POAG. The same in PACG ranged between 0.57 and 0.86. Sensitivities at 95% specificity ranged from 13% to 70% in POAG, and from 10% to 67% in PACG. AUCs of peripapillary RNFL thickness ranged between 0.51 for the temporal sector and 0.91 for the inferonasal sector in POAG. The same in PACG ranged between 0.61 and 0.87. Sensitivities at 95% specificity ranged from 8% to 68% in POAG, and from 2% to 67% in PACG. AUCs of all peripapillary vessel density measurements were comparable (p>0.05) to the corresponding RNFL thickness measurements in both POAG and PACG.ConclusionsDiagnostic ability of peripapillary vessel density parameters of OCTA, especially the inferotemporal sector measurement, was good in POAG and PACG. Diagnostic abilities of vessel density measurements were comparable to RNFL measurements in both POAG and PACG.