Mucosal epithelium in health and disease

The intestinal epithelium has emerged as one of the links between the innate and adaptive immune systems. Novel roles have been elucidated for its participation in antigen uptake and presentation, costimulatory signaling, and intestinal homeostasis. Its concomitant interaction with immune cells and...

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Bibliographic Details
Published inCurrent molecular medicine Vol. 5; no. 6; p. 549
Main Authors Ponda, Prashant P, Mayer, Lloyd
Format Journal Article
LanguageEnglish
Published Netherlands 01.09.2005
Subjects
Antigen Presentation - immunology
Antigens, Surface - metabolism
Chemokines - metabolism
Cytokines - metabolism
Humans
Immunity, Cellular
Immunity, Innate
Immunity, Mucosal
Intestinal Mucosa - immunology
Intestinal Mucosa - microbiology
Membrane Glycoproteins - metabolism
Models, Biological
Receptors, Cell Surface - metabolism
Toll-Like Receptors
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Summary:The intestinal epithelium has emerged as one of the links between the innate and adaptive immune systems. Novel roles have been elucidated for its participation in antigen uptake and presentation, costimulatory signaling, and intestinal homeostasis. Its concomitant interaction with immune cells and commensal flora demonstrates the epithelium's multifaceted responsibility in protecting against intestinal pathology while maintaining immune competence. Its functional capacity is now more clearly defined in disease states such as celiac disease, Crohn's disease, and ulcerative colitis and in maintaining intestinal integrity through toll-like receptor signaling pathways.
ISSN:1566-5240
DOI:10.2174/1566524054863933