Identification of nitric oxide donors by biomimetic HTS application

Metalloporphyrin catalyzed biomimetic oxidation was used for the identification of nitric oxide (NO) donors with diverse chemical structure. Methodology was validated by testing known NO donors. Efficient automation of the test allowed us to investigate a subset of our corporate library. Several hit...

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Bibliographic Details
Published inCombinatorial chemistry & high throughput screening Vol. 8; no. 4; p. 347
Main Authors Balogh, György T, Dalmadi, Balázs, Bielik, Attila, Keserü, György M
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.06.2005
Subjects
Animals
Biomimetics
Combinatorial Chemistry Techniques
Drug Evaluation, Preclinical - methods
Hydrogen Peroxide - metabolism
Male
Metalloporphyrins - chemistry
Metalloporphyrins - metabolism
Metalloporphyrins - pharmacology
Microsomes, Liver
Nitric Oxide Donors - pharmacology
Rats
Rats, Wistar
Reproducibility of Results
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Summary:Metalloporphyrin catalyzed biomimetic oxidation was used for the identification of nitric oxide (NO) donors with diverse chemical structure. Methodology was validated by testing known NO donors. Efficient automation of the test allowed us to investigate a subset of our corporate library. Several hits identified in this campaign were validated in both the chemical and also microsomal model that revealed all hits to be active in the biological system, as well. One of the hits showed comparable activity to V-PYRRO/NO, the prototypic liver selective NO donor.
ISSN:1386-2073
DOI:10.2174/1386207054020831