A family with massive acute vitamin D intoxication

Acute massive vitamin D overdosage occurred in a family after eating food cooked in a nut oil containing 5 million units of vitamin D3/ml. The plasma vitamin D was 55 and 60 i.u./ml in the father and mother respectively, and 9·6 i.u./ml in their 11-month-old infant (normal range, 0-1·6 i.u./ml). All...

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Bibliographic Details
Published inPostgraduate medical journal Vol. 55; no. 650; pp. 897 - 902
Main Authors Down, P. F., Polak, A., Regan, R. J.
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.12.1979
Subjects
Acute Disease
Adult
Case Reports
Cholecalciferol - poisoning
Female
Humans
Hypercalcemia - chemically induced
Hypercalcemia - drug therapy
Hypercalcemia - genetics
Infant
Male
Nephrocalcinosis - chemically induced
Nuts
Oils
Phosphates - therapeutic use
Prednisone - therapeutic use
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Summary:Acute massive vitamin D overdosage occurred in a family after eating food cooked in a nut oil containing 5 million units of vitamin D3/ml. The plasma vitamin D was 55 and 60 i.u./ml in the father and mother respectively, and 9·6 i.u./ml in their 11-month-old infant (normal range, 0-1·6 i.u./ml). All the family presented with symptoms of hypercalcaemia and the infant responded quickly to prednisone. After steroids had failed to control the hypercalcaemia in the parents, neutral phosphate was successful, although necessary for 9 months. Before phosphate therapy it was shown that both parents were in strongly negative calcium balance, indicating that the vitamin D was mobilizing calcium from bone. Eleven years later all 3 patients are well but a renal biopsy in one of them shows persistent nephrocalcinosis.
ISSN:0032-5473
1469-0756
DOI:10.1136/pgmj.55.650.897