Focal fits during chlorambucil therapy

An elderly man receiving chlorambucil for chronic lymphatic leukaemia developed focal fits. The onset and frequency were dose related. There was no evidence of metabolic disturbance or of meningeal leukaemia. Although reported in children and well recognized in animals, chlorambucil-induced fits in...

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Bibliographic Details
Published inPostgraduate medical journal Vol. 55; no. 649; pp. 806 - 807
Main Authors Naysmith, A., Robson, R. H.
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.11.1979
Subjects
Age Factors
Case Reports
Chlorambucil - adverse effects
Chlorambucil - therapeutic use
Epilepsies, Partial - chemically induced
Humans
Leukemia, Lymphoid - drug therapy
Male
Middle Aged
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Summary:An elderly man receiving chlorambucil for chronic lymphatic leukaemia developed focal fits. The onset and frequency were dose related. There was no evidence of metabolic disturbance or of meningeal leukaemia. Although reported in children and well recognized in animals, chlorambucil-induced fits in an adult have not been previously recorded.
ISSN:0032-5473
1469-0756
DOI:10.1136/pgmj.55.649.806