Management of endometrial cancer in Latin America: raising the standard of care and optimizing outcomes

Molecular characterization of endometrial cancer is allowing for increased understanding of the natural history of tumors and paving a more solid pathway for novel therapies. It is becoming increasingly apparent that molecular classification is superior to histological classification in terms of rep...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of gynecological cancer Vol. 34; no. 8; p. 1263
Main Authors Blanco, Albano, Nogueira-Rodrigues, Angélica, Carvalho, Filomena Marino, Giornelli, Gonzalo, Mirza, Mansoor Raza
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group Ltd 01.08.2024
Subjects
Adenosarcoma
Carcinosarcoma
Endometrial Neoplasms
Endometrial Neoplasms - pathology
Endometrial Neoplasms - therapy
Female
Humans
Latin America - epidemiology
Review
Standard of Care
Uterine Cancer
Latin America
Uterine Cancer
Endometrial Neoplasms
Adenosarcoma
Carcinosarcoma
Online AccessGet full text

Cover

More Information
Summary:Molecular characterization of endometrial cancer is allowing for increased understanding of the natural history of tumors and paving a more solid pathway for novel therapies. It is becoming increasingly apparent that molecular classification is superior to histological classification in terms of reproducibility and prognostic discrimination. In particular, the Proactive Molecular Risk Classifier for Endometrial Cancer allows classification of endometrial cancer into groups very close to those determined by the Cancer Genome Atlas Research Network—that is, DNA polymerase epsilon-mutated, mismatch repair-deficient, p53 abnormal, and non-specific molecular profile tumors. The transition from the chemotherapy era to the age of targeted agents and immunotherapy, which started later in endometrial cancer than in many other tumor types, requires widespread availability of specialized pathology and access to novel agents. Likewise, surgical expertise and state-of-the-art radiotherapy modalities are required to ensure adequate care. Nevertheless, Latin American countries still face considerable barriers to implementation of international guidelines. As we witness the dawn of precision medicine as applied to endometrial cancer, we must make continued efforts towards improving the quality of care in this region. The current article discusses some of these challenges and possible solutions.
ISSN:1048-891X
1525-1438
DOI:10.1136/ijgc-2023-005017