Comparison of the radioisotope dilution-coated charcoal method and a microbiological method (L. leichmannii) for measuring vitamin B12 in serum

A comparison has been made of the radioisotope dilution-coated charcoal method and a microbiological assay (with L. leichmannii as test organism) for determining the concentration of vitamin B12 in serum. A satisfactory correlation was found between the results of the two methods. Under appropriate...

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Bibliographic Details
Published inJournal of clinical pathology Vol. 19; no. 6; pp. 610 - 613
Main Authors Raven, J. L., Walker, P. L., Barkhan, P.
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group Ltd and Association of Clinical Pathologists 01.11.1966
Subjects
Biological Assay
Charcoal
Cobalt Isotopes
Lactobacillus
Radioisotope Dilution Technique
Vitamin B 12 - blood
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Summary:A comparison has been made of the radioisotope dilution-coated charcoal method and a microbiological assay (with L. leichmannii as test organism) for determining the concentration of vitamin B12 in serum. A satisfactory correlation was found between the results of the two methods. Under appropriate conditions the reproducibility of the radioisotope method compared favourably with that of the microbiological method.
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ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.19.6.610