The adenomatous polyposis coli protein

Mutations in the adenomatous polyposis coli (APC) gene are associated with most colorectal cancers. The APC protein has been implicated in many aspects of tumour development. This article will discuss recent data suggesting that APC may have multiple functions in the cell. First, APC is a component...

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Bibliographic Details
Published inMolecular pathology Vol. 52; no. 4; pp. 169 - 173
Main Author Nathke, I. S.
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group Ltd and Association of Clinical Pathologists 01.08.1999
Subjects
Adenomatous Polyposis Coli Protein
Cell Physiological Phenomena
Colorectal Neoplasms - physiopathology
Cytoskeletal Proteins - physiology
Humans
Neoplasm Proteins - physiology
Signal Transduction - physiology
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Summary:Mutations in the adenomatous polyposis coli (APC) gene are associated with most colorectal cancers. The APC protein has been implicated in many aspects of tumour development. This article will discuss recent data suggesting that APC may have multiple functions in the cell. First, APC is a component of the Wnt signalling pathway; second, APC may have a role in cell migration; finally, APC may regulate proliferation and apoptosis.
Bibliography:href:molpath-52-169.pdf
PMID:10694935
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ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1366-8714
1472-4154
DOI:10.1136/mp.52.4.169