Concomitant angiosarcoma and lymphoproliferative disorder in solid organ transplant recipients

• Published in: Clinical sarcoma research Vol. 4; no. 1; p. 15
• Main Authors: Baer, Lea N, Savage, David G, Hibshoosh, Hanina H, Kalinsky, Kevin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 31.10.2014; BioMed Central
• Subjects: Case Report; Angiosarcoma; Posttransplant lymphoproliferative disorder; Solid organ transplant
• ISSN: 2045-3329; 2045-3329
• DOI: 10.1186/2045-3329-4-15

An increased risk of posttransplant malignancy has been consistently reported following various solid organ transplants. The malignancies most commonly encountered are non-melanoma skin cancers, carcinomas of lung or breast and posttransplant lymphoproliferative disorders. Angiosarcoma, an uncommon vascular mesenchymal neoplasm, is rare in the posttransplant setting. This report describes two patients who developed high-grade angiosarcoma following a solid organ transplant. Notably, in both patients, the diagnosis of angiosarcoma was preceded by diagnosis of a lymphoproliferative disorder with monoclonal immunoglobulin heavy chain rearrangement.