Potential Epigenetic Targets for Combating Alzheimer's disease

Memory remains an obligatory regime of human brain and impaired memory causes serious obstacles in our everyday life. Alzheimer's disease (AD) is one such neurodegenerative disease which is mostly affects elderly population, above the age of 60; marked by cognitive impairment of memory. Besides...

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Published inMini reviews in medicinal chemistry
Main Authors Pandey, Dheeraj, Pal, Tiyas, Sharma, Abha, Flora, Sjs
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2021
Subjects
Glial Cell
Sirtuins
HDACs
Dicer
MiRNA
DNA methylation
Epigenetics
Alzheimer
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Summary:Memory remains an obligatory regime of human brain and impaired memory causes serious obstacles in our everyday life. Alzheimer's disease (AD) is one such neurodegenerative disease which is mostly affects elderly population, above the age of 60; marked by cognitive impairment of memory. Besides the known targets of AD against the several etiologies known till date, the zone of epigenetics has recently evolved as an ingenious field in AD. Epigenetic modifications do not affect DNA sequence but only long-term gene expression. Considering the multifactorial complex nature of AD, we herein discuss the various epigenetic targets which might give rise to potential therapeutic approaches. We reviewed the possible epigenetic targets for AD like HDAC, Sirtuins, glial cells, miRNA and epigenetic modifications like DNA methylation. A deeper insight into these target areas can surely evolve AD diagnosis and therapeutics.
ISSN:1875-5607
DOI:10.2174/1389557521999201228191427