Comparative Review on Effects of Pien Tze Huang and AnGong NiuHuang Pill and their Potential on Treatment of Central Nervous System Diseases

• Published in: Mini reviews in medicinal chemistry
• Main Authors: Liu, Congsheng, Chen, Zhiliang, Wu, Sharon L Y, Chow, Tony C H, Cheng, Rufina S Y, Lee, Jocy T C, Yew, David T
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2022
• Subjects: Moschus; cardioprotection; Composite formula; Calculus bovis; neuroprotection; central nervous system
• ISSN: 1875-5607
• DOI: 10.2174/1389557522666220318111730

The ancient composite formulae Angong Niuhuang pill and Pien Tze Huang that were used a few hundred years ago to treat febrile disease and inflammation respectively are found to exert effects benefiting other neurological diseases and conditions. This short review introduces the main constituents of the two formulae, looking into both the cumulative synergetic and possible individual effects of each herb or animal apcoien. In essence, the main effects of Angong Niuhuang pill include antiinflammation, antioxidation, anti-cell death, anticonvulsion, antiedema, antipyretic, antithrombotic, antimicrobial (bacteria, viruses, fungi), neuroprotective effects, and cardiovascular protection. The main effects of Pien Tze Huang include antiinflammation, antioxidation, anti-cell death, antithrombotic, antimicrobial, neuroprotective effects, and cardiovascular protection. Comparing both composites, similarities of the effects and part of the components are found, showing some pharmacological evidence. This review casts light on research on the effects of neuroprotective and cardiovascular protective mechanisms as well as treatment mechanisms for cerebral accidents in the integrative medicine perspective.