Synthesis and Biological Activities of Oxadiazole Derivatives: A Review

• Published in: Mini reviews in medicinal chemistry Vol. 16; no. 10; p. 825
• Main Authors: Vaidya, Ankur, Jain, Shweta, Jain, Priyanka, Jain, Prachi, Tiwari, Nidhi, Jain, Roshni, Jain, Rashi, Jain, Abhishek K, Agrawal, Ram K
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2016
• Subjects: Analgesics - chemical synthesis; Analgesics - chemistry; Analgesics - pharmacology; Angiogenesis Inhibitors - chemical synthesis; Angiogenesis Inhibitors - chemistry; Angiogenesis Inhibitors - pharmacology; Animals; Anti-Infective Agents - chemical synthesis; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Anti-Inflammatory Agents - chemical synthesis; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Anticonvulsants - chemical synthesis; Anticonvulsants - chemistry; Anticonvulsants - pharmacology; Chemistry Techniques, Synthetic - methods; Drug Discovery; Humans; Oxadiazoles - chemical synthesis; Oxadiazoles - chemistry; Oxadiazoles - pharmacology
• ISSN: 1875-5607
• DOI: 10.2174/1389557516666160211120835

Recently, there has been wide interest in compounds containing the oxadiazole scaffold because of their unique chemical structure and their broad spectrum of biological properties. This review provides readers with an overview of the main synthetic methodologies for oxadiazoles and of their broad spectrum of pharmacological activities such as, anti-microbial, anti-fungal activity, antiviral, anti-tubercular, anti-inflammatory, anti-convulsant, anti-angiogenic, anti-proliferative, analgesic, anti-oedema and in alzheimer activity, which were reported over the past years.