Splicing of the glutamate transporter EAAT2: a candidate gene of amyotrophic lateral sclerosis

In vitro expression studies suggested that proteins translated from these transcripts were rapidly degraded and show a dominant negative effect on normal EAAT2 protein which appears to be the predominat glutamate transporter in the CNS. 3 A loss of EAAT2 can lead to neuronal degeneration through abn...

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Published inJournal of neurology, neurosurgery and psychiatry Vol. 65; no. 6; p. 954
Main Authors MEYER, THOMAS, MÜNCH, CHRISTOPH, LIEBAU, STEFAN, FROMM, ANDREA, SCHWALENSTÖCKER, BIRGIT, VÖLKEL, HELGE, LUDOLPH, ALBERT C
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group LTD 01.12.1998
BMJ Group
Subjects
Alternative Splicing - genetics
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - genetics
Cloning
Glutamates - genetics
Humans
Letters to the Editor
Polymerase Chain Reaction
Protein Splicing - genetics
Proteins
RNA, Messenger - genetics
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Summary:In vitro expression studies suggested that proteins translated from these transcripts were rapidly degraded and show a dominant negative effect on normal EAAT2 protein which appears to be the predominat glutamate transporter in the CNS. 3 A loss of EAAT2 can lead to neuronal degeneration through abnormal accumulation of the potential neurotoxin glutamate and excitotoxic mechanisms.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.65.6.954