Pupillary autonomic denervation and diabetes mellitus

• Published in: British journal of ophthalmology Vol. 86; no. 11; p. 1319
• Main Authors: Pittasch, D, Lobmann, R, Lehnert, H, Behrens-Bauman, W
• Format: Journal Article
• Language: English
• Published: BMA House, Tavistock Square, London, WC1H 9JR BMJ Publishing Group Ltd 01.11.2002; BMJ Publishing Group LTD; Copyright 2002 British Journal of Ophthalmology
• Subjects: Autonomic Nervous System Diseases - etiology; Cocaine; Dark Adaptation - physiology; Diabetes; diabetes mellitus; Diabetic Neuropathies - complications; Humans; Mailbox; Pupil Disorders - etiology; pupillary autonomic denervation
• ISSN: 0007-1161; 1468-2079
• DOI: 10.1136/bjo.86.11.1319

Patients without any systemic diabetic long term complication defined as CAN, peripheral sensomotor neuropathy, retinopathy, and nephropathy had no significant differences in their DAP compared to the probands. [...]it is of interest if patients in this study with CAN also significantly differ in their pupillary responses to cocaine, and if patients without CAN possibly have other diabetic long term complications or increased glycosylated haemoglobin levels, which may correlate with the small DAP. 4 Nevertheless, this study by Cahill et al also clearly indicates that screening for pupillary dysfunction is mandatory as early as possible to prevent the sequelae of other autonomic neuropathic disorders.