Circulating levels of IGF-I and IGF-binding protein-1 throughout pregnancy: relation to birthweight and maternal weight
Abstract Serum levels of IGF-I and IGF-binding protein (IGFBP-1) have been determined in the maternal circulation between 11 and 42 weeks of gestation in women not in labour (n=335) and in the maternal and fetal circulations at the time of delivery between 37 and 42 weeks (n=55). Maternal serum (MS)...
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Published in | Journal of endocrinology Vol. 148; no. 2; pp. 303 - 309 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
England
BioScientifica
01.02.1996
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Subjects | |
Online Access | Get full text |
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Summary: | Abstract Serum levels of IGF-I and IGF-binding protein (IGFBP-1) have been determined in the maternal circulation between 11 and 42 weeks of gestation in women not in labour (n=335) and in the maternal and fetal circulations at the time of delivery between 37 and 42 weeks (n=55). Maternal serum (MS) IGF-I levels increased during pregnancy and showed a significant positive correlation with maternal weight (P=0·0033) but no correlation with birthweight. The MS IGFBP-1 levels did not change during the second and third trimesters and showed a negative correlation with birthweight, maternal weight, placental weight and MS glucose (P=0·0002, P<0·0001, P=0·047, P=0·024 respectively). MS IGFBP-1 levels were higher in small-for-gestational age babies than in average-for-gestational weight babies (P=0·026) and lower in the large-for-gestational weight group (P=0·048). There was a significant rise in mean MS IGFBP-1 levels during labour (P=0·0005). These findings suggest that IGFBP-1 may be an important factor in pathological growth retardation. Journal of Endocrinology (1996) 148, 303–309 |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-0795 1479-6805 |
DOI: | 10.1677/joe.0.1480303 |