The Role of Sesamin in Targeting Neurodegenerative Disorders: A Systematic Review

Neurodegenerative Diseases (NDs) are characterized by progressive neuronal deterioration as a result of several pathogenesis mechanisms. Phytochemicals, including sesamin with multitarget activities, have been studied widely. In this review, we aim to survey the neuroprotective effects of sesamin on...

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Bibliographic Details
Published inMini reviews in medicinal chemistry Vol. 23; no. 6; p. 756
Main Authors Ghaderi, Mohammad Amin, Emami, Seyed Ahmad, Beirak Olia, Mahla Daliri, Javadi, Behjat
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2023
Subjects
Alzheimer Disease - drug therapy
Alzheimer Disease - pathology
Dioxoles - chemistry
Dioxoles - pharmacology
Dioxoles - therapeutic use
Humans
Lignans - chemistry
Lignans - pharmacology
Lignans - therapeutic use
Parkinson Disease - drug therapy
Parkinson Disease - pathology
alzheimer’s disease
natural products
Sesamin
neurodegenerative disease
systematic review
parkinson's disease
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Summary:Neurodegenerative Diseases (NDs) are characterized by progressive neuronal deterioration as a result of several pathogenesis mechanisms. Phytochemicals, including sesamin with multitarget activities, have been studied widely. In this review, we aim to survey the neuroprotective effects of sesamin on NDs and its mechanisms of action. Searching GoogleScholar, PubMed, and Science Direct databases, we reviewed original English language articles on sesamin effects against NDs, specifically Alzheimer's Disease (AD) and Parkinson's Disease (PD), either in vivo or in vitro settings, with no time limitation. Sesamin has been reported to interfere with NDs progression through its antioxidative, antiinflammatory, and antiapoptotic actions in most of the retrieved studies. Sesamin also can prevent amyloid-β aggregation in AD models and elevate dopamine levels in PD-induced models. The results of this study revealed the beneficial effects of sesamin in the prevention and management of NDs, including AD and PD; however, no clinical data supporting these effects in humans is available, which highlights the need for designing clinical trials to evaluate the efficacy, proper dosage, pharmacokinetics aspects, and possible side effects of sesamin in humans.
ISSN:1875-5607
DOI:10.2174/1389557522666220523112027