MicroRNAs and cancer; an overview

MiRNAs are a family of small, endogenous, and evolutionarily conserved non-coding ribonucleic acids that have been involved in the regulation of several essential, cellular, and functional processes. MicroRNAs are known to play key roles in all types of cancer and function as oncogenes (oncomirs) or...

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Bibliographic Details
Published inCurrent pharmaceutical biotechnology Vol. 15; no. 5; p. 430
Main Authors Tutar, Lutfi, Tutar, Esen, Tutar, Yusuf
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2014
Subjects
Animals
Biomarkers, Tumor - analysis
Biomarkers, Tumor - genetics
Gene Expression Regulation, Neoplastic - genetics
Humans
MicroRNAs - biosynthesis
MicroRNAs - genetics
MicroRNAs - physiology
Neoplasms - diagnosis
Neoplasms - genetics
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Summary:MiRNAs are a family of small, endogenous, and evolutionarily conserved non-coding ribonucleic acids that have been involved in the regulation of several essential, cellular, and functional processes. MicroRNAs are known to play key roles in all types of cancer and function as oncogenes (oncomirs) or tumour-suppressors in up-regulation or down-regulation processes respectively. MiRNAs have potential power to be examined as prognostic and diagnostic biomarkers. Modulating miRNAs, based on two major approaches (miRNA mimics and miRNA antagonists), is used for clinical development of therapeutic miRNAs. This review emphasizes the latest discovery in the field of miRNA research involved in cancer, biomarkers, and therapeutics.
ISSN:1873-4316
DOI:10.2174/1389201015666140519095304