Structure and Function of the Important Internalins of Listeria monocytogenes

Listeria monocytogenes, a facultative intracellular gram-positive pathogen, is the causative agent of the disease listeriosis. The virulence of this intracellular bacterium is dependent on the coordinated activity of various bacterial factors, which are in turn tightly controlled by a specific set o...

Full description

Saved in:
Bibliographic Details
Published inCurrent protein & peptide science Vol. 22; no. 8; p. 620
Main Author Mir, Shabir A
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2021
Subjects
Bacterial Proteins - chemistry
Bacterial Proteins - metabolism
Listeria monocytogenes - chemistry
Listeria monocytogenes - metabolism
Listeria monocytogenes
Listeriosis
internalins
pathogenesis
virulence
virulence factors
Online AccessGet more information

Cover

More Information
Summary:Listeria monocytogenes, a facultative intracellular gram-positive pathogen, is the causative agent of the disease listeriosis. The virulence of this intracellular bacterium is dependent on the coordinated activity of various bacterial factors, which are in turn tightly controlled by a specific set of regulators. The various virulence factors employed by L. monocytogenes for its infection cycle are well reported in literature. Although the internalins of L. monocytogenes have been studied in detail, their structural details are currently scattered and fragmented. Therefore, in the current review, we provide a brief account of the existing knowledge on structural details of the key internalins of L. monocytogenes and also highlight the recent advances in their functional aspects.
ISSN:1875-5550
DOI:10.2174/1389203722666210902163300