Peptide modules for overcoming barriers of nucleic acids transport to cells

Absence of safe and efficient methods of nucleic acids delivery is one of the major issues which limits the development of human gene therapy. Highly efficient viral vectors raise questions due to safety reasons. Among non-viral vectors peptide-based carriers can be considered as good candidates for...

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Bibliographic Details
Published inCurrent topics in medicinal chemistry Vol. 16; no. 3; p. 330
Main Authors Egorova, Anna A, Kiselev, Anton V
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2016
Subjects
Animals
Cells - metabolism
Drug Carriers - chemistry
Drug Carriers - metabolism
Humans
Nucleic Acids - chemistry
Nucleic Acids - metabolism
Peptides - chemistry
Peptides - metabolism
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Summary:Absence of safe and efficient methods of nucleic acids delivery is one of the major issues which limits the development of human gene therapy. Highly efficient viral vectors raise questions due to safety reasons. Among non-viral vectors peptide-based carriers can be considered as good candidates for the development of "artificial viruses"--multifunctional polyplexes that mimic viruses. Suggested strategy to obtain multifunctionality is to combine several peptide modules into one modular carrier. Different kinds of peptide modules are needed for successful overcoming barriers of nucleic acids transport into the cells. Design of such modules and establishment of structure-function relationships are issues of importance to researchers working in the field of nucleic acids delivery.
ISSN:1873-4294
DOI:10.2174/1568026615666150812120755