Colchicine in Renal Diseases: Present and Future

Colchicine is a lipophilic alkaloid drug, which exhibits ant-inflammatory and anti-fibrotic properties. Cardinal mechanisms of action of colchicine are the disruption of the microtubule system and the inhibition of neutrophil adhesion and recruitment. Colchicine is indicated in the prevention and tr...

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Bibliographic Details
Published inCurrent pharmaceutical design Vol. 24; no. 6; p. 675
Main Authors Marinaki, Smaragdi, Skalioti, Chrysanthi, Boletis, J N
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2018
Subjects
chronic kidney disease
fibrosis
lipophilic alkaloid
Colchicine
gouty arthritis
inflammation
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Summary:Colchicine is a lipophilic alkaloid drug, which exhibits ant-inflammatory and anti-fibrotic properties. Cardinal mechanisms of action of colchicine are the disruption of the microtubule system and the inhibition of neutrophil adhesion and recruitment. Colchicine is indicated in the prevention and treatment of gouty arthritis and familial Mediterranean fever. In this review, we summarize current and potentially future pharmacologic activities of colchicine in various renal disease entities along with pharmacokinetic and pharmacodynamic properties. Additionally, we will refer to main interactions of colchicine with medications used in renal medicine, as well as dosing recommendations in patients with reduced glomerular filtration rate.
ISSN:1873-4286
DOI:10.2174/1381612824666180123101313