Vascular effects of flavonoids

Flavonoids are natural plant-derived polyphenolic compounds with various biological properties particularly in the cardiovascular system, including antiatherogenic, antioxidant, vasodilation, antihypertensive, and antiplatelet activities. These biological properties have been evaluated in several ex...

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Bibliographic Details
Published inCurrent medicinal chemistry Vol. 23; no. 1; p. 87
Main Authors Almeida Rezende, Bruno, Pereira, Aline Carvalho, Cortes, Steyner F, Lemos, Virginia Soares
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2016
Subjects
Animals
Antihypertensive Agents - pharmacology
Antihypertensive Agents - therapeutic use
Blood Vessels - drug effects
Cardiovascular Diseases - drug therapy
Cardiovascular System - drug effects
Flavonoids - pharmacology
Flavonoids - therapeutic use
Humans
Vasodilation - drug effects
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Summary:Flavonoids are natural plant-derived polyphenolic compounds with various biological properties particularly in the cardiovascular system, including antiatherogenic, antioxidant, vasodilation, antihypertensive, and antiplatelet activities. These biological properties have been evaluated in several experimental and clinical studies. In addition, extensive reviews have discussed the antiatherogenic effect of these polyphenols. However, limited studies have investigated the potential therapeutic vascular effects of these compounds. This review brings together some recent studies, to establish the different signaling pathways involved in the molecular mechanisms that underlie the vasodilation induced by flavonoids.
ISSN:1875-533X
DOI:10.2174/0929867323666151111143616