HIV-1 TAT and IMMUNE DYSREGULATION in AIDS PATHOGENESIS: a THERAPEUTIC TARGET

The HIV-1 transactivator Tat protein plays a key role in AIDS pathogenesis. Besides the Tat role as activator of HIV-1 transcription, it exerts several important functions on infected and uninfected cells. In fact, HIV-1 Tat is released by infected cells and is taken up by neighboring cells. In this...

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Bibliographic Details
Published inCurrent drug targets Vol. 17; no. 1; p. 33
Main Authors Chiozzini, Chiara, Toschi, Elena
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2016
Subjects
Anti-HIV Agents - pharmacology
Drug Discovery
HIV Infections - drug therapy
HIV Infections - immunology
HIV Infections - virology
HIV-1 - drug effects
HIV-1 - pathogenicity
HIV-1 - physiology
Humans
Peptide Fragments - metabolism
tat Gene Products, Human Immunodeficiency Virus - metabolism
Viral Regulatory and Accessory Proteins - metabolism
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Summary:The HIV-1 transactivator Tat protein plays a key role in AIDS pathogenesis. Besides the Tat role as activator of HIV-1 transcription, it exerts several important functions on infected and uninfected cells. In fact, HIV-1 Tat is released by infected cells and is taken up by neighboring cells. In this way it regulates expression of viral and cellular genes and it modulates several cellular pathways leading to HIV-1 infection spreading and immune dysregulation. So far, Tat protein and the cellular pathways targeted by Tat may represent potential targets for new anti-HIV therapeutic approaches and vaccine development against AIDS.
ISSN:1873-5592
DOI:10.2174/1389450116666150825110658