How far you can trust c-ANCA?

The suspicion of a serious condition arises if a smoker is coughing and losing weight constantly. Serology and imaging are great options for diagnosis, but what is their specificity? A 62-year-old man presented with persistent cough, weight loss and hypoxia. A chest x-ray revealed bilateral intersti...

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Bibliographic Details
Published inBMJ case reports Vol. 2013; p. bcr2013008555
Main Authors Akturk, Halis Kaan, Vashisht, Priyanka
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group LTD 01.03.2013
BMJ Publishing Group
SeriesCase Report
Subjects
Antibodies, Antineutrophil Cytoplasmic - blood
Biopsy
Black
Cough
Cryptogenic Organizing Pneumonia - diagnosis
Diagnosis, Differential
Humans
Hypoxia
Laboratories
Lung diseases
Male
Middle Aged
Pneumonia
Radiography, Thoracic
Sensitivity and Specificity
Unusual Association of Diseases/Symptoms
USA/Canada
Weight Loss
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Summary:The suspicion of a serious condition arises if a smoker is coughing and losing weight constantly. Serology and imaging are great options for diagnosis, but what is their specificity? A 62-year-old man presented with persistent cough, weight loss and hypoxia. A chest x-ray revealed bilateral interstitial infiltrates. Treatment with several antibiotics failed. Serological results showed antineutrophil cytoplasmic antibodies (c-ANCA) positivity. However, biopsy result indicated cryptogenic organising pneumonia. This case report discloses the differential diagnosis of c-ANCA positive interstitial lung disease in detail.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
ObjectType-Article-3
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2013-008555