The Potential Application of Biomaterials in Cardiac Stem Cell Therapy

• Published in: Current medicinal chemistry Vol. 23; no. 6; p. 589
• Main Authors: Sahito, Raja Ghazanfar Ali, Sureshkumar, Poornima, Sotiriadou, Isaia, Srinivasan, Sureshkumar Perumal, Sabour, Davood, Hescheler, Jürgen, Pfannkuche, Kurt, Sachinidis, Agapios
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2016
• Subjects: Animals; Biocompatible Materials - chemistry; Heart - physiology; Humans; Myocardium - cytology; Regeneration; Regenerative Medicine - methods; Stem Cell Transplantation - methods; Stem Cells - cytology; Tissue Engineering - methods; Tissue Scaffolds - chemistry
• ISSN: 1875-533X
• DOI: 10.2174/092986732306160303151041

Biomaterials play a vital role in the field of regenerative medicine and tissue engineering. To date, a large number of biomaterials have been used in cardiovascular research and application. Recently, biomaterials have held a lot of promise in cardiac stem cell therapy. They are used in cardiac tissue engineering to form scaffolds for cellular transplantation, promote angiogenesis, enhance transplanted cell engraftment or influence cell migration. The science of biomaterial designing has evolved to an extent where they can be designed to mimic the microenvironment of a cardiac tissue in vivo and contribute in deciding the fate of transplanted stem cells and induce cardiac lineage oriented stem cell differentiation. In this review, we focus on biomaterials used in cardiovascular stem cell research, tissue engineering and regenerative medicine and conclude with an outlook on future impacts of biomaterial in medical sciences.