Therapeutic angiogenesis: recent and future prospects of gene therapy in peripheral artery disease

• Published in: Current gene therapy Vol. 14; no. 4; p. 300
• Main Authors: Tanaka, Michiko, Taketomi, Kikuko, Yonemitsu, Yoshikazu
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2014
• Subjects: Carrier Proteins - genetics; Clinical Trials as Topic; Fibroblast Growth Factors - genetics; Genetic Therapy - methods; Genetic Vectors; Hepatocyte Growth Factor - genetics; Humans; Neovascularization, Physiologic - genetics; Peripheral Arterial Disease - genetics; Peripheral Arterial Disease - therapy; Vascular Endothelial Growth Factor A - genetics
• ISSN: 1875-5631
• DOI: 10.2174/156652321404140902124838

Peripheral artery disease (PAD) is a highly prevalent disease, which still has unmet medical needs. Therapeutic angiogenesis for PAD, achieved by gene therapy, has achieved promising results in preclinical studies and early-phase clinical trials, yet few late-phase clinical trials have been conducted or have not shown efficacy. This article provides an overview of the progression of angiogenesis research in gene therapy field as it applies to PAD. The focus of angiogenic growth factors and clinical trials is introduced as a frontier of therapeutic angiogenesis. The article also includes insights into future directions from bench to bedside.