Natural Macromolecules with Protective and Antitumor Activity

• Published in: Anti-cancer agents in medicinal chemistry Vol. 18; no. 5; p. 675
• Main Authors: Oana, Cioanca, Adriana, Trifan, Mircea, Cornelia, Dragos, Scripcariu, Monica, Hancianu
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2018
• Subjects: Agaricales - chemistry; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Biological Products - chemistry; Biological Products - isolation & purification; Biological Products - pharmacology; Cell Proliferation - drug effects; Humans; Lectins - chemistry; Lectins - isolation & purification; Lectins - pharmacology; Macromolecular Substances - chemistry; Macromolecular Substances - isolation & purification; Macromolecular Substances - pharmacology; Neoplasms - drug therapy; Neoplasms - pathology; Polysaccharides - chemistry; Polysaccharides - isolation & purification; Polysaccharides - pharmacology; apoptosis; plant lectins; receptors; mechanism; mushroom; Cancer
• ISSN: 1875-5992
• DOI: 10.2174/1871520618666180425115029

This review summarizes the literature data regarding plant lectins as novel drug sources in the prevention or treatment of cancer. Moreover, such compounds have been described as natural toxins that possess different biological activities (cytotoxic, antitumor, antimutagenic and anticarcinogenic properties). This activity depends greatly on their structure and affinity. Most of the mushroom heterosides are known as β-glucans with β-(1→3)-glycosidic bonds. It is thought that their conformation, bonds, molecular size can modulate the immune response by triggering different receptors. The mechanism on normal and tumor cells of various plant and mushroom polysaccharides and lectins is briefly presented in this paper.