Real-world risk score for hepatocellular carcinoma (RWS-HCC): a clinically practical risk predictor for HCC in chronic hepatitis B

Out of the five risk scores evaluated, the Chinese University (CU)-HCC and Guide with Age, Gender, HBV DNA, Core promoter mutations and Cirrhosis (GAG-HCC) performed the best. 2 3 However, HBV DNA titres are needed in both scores and additionally, core mutation determination is needed for even bette...

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Published inGut Vol. 65; no. 5; pp. 887 - 888
Main Authors Poh, Zhongxian, Shen, Liang, Yang, Hwai-I, Seto, Wai-Kay, Wong, Vincent W, Lin, Clement Y, Goh, Boon-Bee George, Chang, Pik-Eu Jason, Chan, Henry Lik-Yuen, Yuen, Man-Fung, Chen, Chien-Jen, Tan, Chee-Kiat
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group LTD 01.05.2016
Subjects
Age
Carcinoma, Hepatocellular
Deoxyribonucleic acid
DNA
Gender
Hepatitis
Hepatitis B virus
Hepatitis B, Chronic
Humans
Infections
Liver cancer
Liver cirrhosis
Liver Neoplasms
Mutation
Patients
Risk
Risk Factors
Surveillance
HEPATITIS B
HEPATOCELLULAR CARCINOMA
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Summary:Out of the five risk scores evaluated, the Chinese University (CU)-HCC and Guide with Age, Gender, HBV DNA, Core promoter mutations and Cirrhosis (GAG-HCC) performed the best. 2 3 However, HBV DNA titres are needed in both scores and additionally, core mutation determination is needed for even better prediction in the GAG-HCC. The accuracy of the three validation cohorts was 88.2%, 79.1% and 90.6%, respectively, and the NPV was maintained at 97.0%, 97.9% and 93.0%, respectively. [...]we have developed and validated in different Asian cohorts the RWS-HCC in CHB that requires only four simple routine parameters available in all clinical settings where a patient with CHB infection is seen.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ObjectType-Commentary-2
ISSN:0017-5749
1468-3288
DOI:10.1136/gutjnl-2015-310818