Human in vitro eugenics: close, yet far away
In meiosis, heterozygous genes segregate differently to form different gametes. [...]numerous other processes become activated during meiosis in order to provide the individual with the largest possible array of genetically diverse gametes. All this complex net of tissue-to-tissue cross-talking will...
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| Published in | Journal of medical ethics Vol. 40; no. 11; pp. 738 - 739 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
BMJ Publishing Group
01.11.2014
BMJ Publishing Group LTD |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0306-6800 1473-4257 1473-4257 |
| DOI | 10.1136/medethics-2013-101674 |
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| Abstract | In meiosis, heterozygous genes segregate differently to form different gametes. [...]numerous other processes become activated during meiosis in order to provide the individual with the largest possible array of genetically diverse gametes. All this complex net of tissue-to-tissue cross-talking will simply not happen if generations are shortened down to the embryogenic level before the next generation starts from cells of the previous one. [...]after something like 20 in vitro generations, will a disease manifest in the 21st subject as it would after 20 real generations? |
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| AbstractList | In meiosis, heterozygous genes segregate differently to form different gametes. [...]numerous other processes become activated during meiosis in order to provide the individual with the largest possible array of genetically diverse gametes. All this complex net of tissue-to-tissue cross-talking will simply not happen if generations are shortened down to the embryogenic level before the next generation starts from cells of the previous one. [...]after something like 20 in vitro generations, will a disease manifest in the 21st subject as it would after 20 real generations? |
| Author | da Fonseca, Flávio Guimarães Carvalho, Nara Pereira Ribeiro, Daniel Mendes Stancioli, Brunello |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23943786$$D View this record in MEDLINE/PubMed |
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| Copyright | Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions 2014 BMJ Publishing Group Ltd and the Institute of Medical Ethics Copyright: 2014 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions |
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| DOI | 10.1136/medethics-2013-101674 |
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| References | Krejci, Altmannova, Spirek 2012; 40 Chocu, Calvel, Rollada 2012; 58 24603035 - J Med Ethics. 2014 Nov;40(11):741-3 23557913 - J Med Ethics. 2014 Nov;40(11):725-31 |
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| Snippet | In meiosis, heterozygous genes segregate differently to form different gametes. [...]numerous other processes become activated during meiosis in order to... |
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| SubjectTerms | Diploidy Disease Embryonic cells Embryonic stem cells Eugenics Female Gametes Genetic disorders Genetic engineering Genetic Engineering - ethics Genome, Human Germ cells Haploidy Humans In Vitro Techniques - trends Male Meiosis Pluripotent stem cells Spermatogenesis Stem cells Stem Cells - cytology Stem-cell derived gametes Studies |
| Title | Human in vitro eugenics: close, yet far away |
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