Human in vitro eugenics: close, yet far away

In meiosis, heterozygous genes segregate differently to form different gametes. [...]numerous other processes become activated during meiosis in order to provide the individual with the largest possible array of genetically diverse gametes. All this complex net of tissue-to-tissue cross-talking will...

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Published inJournal of medical ethics Vol. 40; no. 11; pp. 738 - 739
Main Authors da Fonseca, Flávio Guimarães, Ribeiro, Daniel Mendes, Carvalho, Nara Pereira, Stancioli, Brunello
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group 01.11.2014
BMJ Publishing Group LTD
Subjects
Diploidy
Disease
Embryonic cells
Embryonic stem cells
Eugenics
Female
Gametes
Genetic disorders
Genetic engineering
Genetic Engineering - ethics
Genome, Human
Germ cells
Haploidy
Humans
In Vitro Techniques - trends
Male
Meiosis
Pluripotent stem cells
Spermatogenesis
Stem cells
Stem Cells - cytology
Stem-cell derived gametes
Studies
Eugenics
Genetic Screening/Testing
Genethics
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ISSN0306-6800
1473-4257
1473-4257
DOI10.1136/medethics-2013-101674

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Summary:In meiosis, heterozygous genes segregate differently to form different gametes. [...]numerous other processes become activated during meiosis in order to provide the individual with the largest possible array of genetically diverse gametes. All this complex net of tissue-to-tissue cross-talking will simply not happen if generations are shortened down to the embryogenic level before the next generation starts from cells of the previous one. [...]after something like 20 in vitro generations, will a disease manifest in the 21st subject as it would after 20 real generations?
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ISSN:0306-6800
1473-4257
1473-4257
DOI:10.1136/medethics-2013-101674